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Peter Thomas Roth Un-Wrinkle Night, 1 Ounce

A best seller! An advanced nighttime moisturizer formulated with our exclusive patent-pending blend of eight powerful anti-aging peptides and neuropeptides plus retinol for maximum results. Clinical studies show a 72% reduction in wrinkles in just 28 days. Exclusive (patent pending) blend of eight powerful, 100% active anti-aging peptides and neuropeptides are combined with Syn-Tacks (new cutting-edge dual-peptide), a mega dose of retinol, glycolic acid, vitamins and skin moisturizers to create this cutting-edge nighttime wrinkle fighting moisturizer. Includes three neuropeptides, Syn-Ake at 4%, SNAP-8 at 10% and Argireline (hexapeptide) at 3% and five peptides, Syn-Coll at 3% and Matrixyl 3000 (a dual peptide) at 3% and Syn-Tacks (a dual peptide) at 1% which helps boost collagen and increases skin firmness and tonicity. Designed to assist in cellular renewal, repair daily environmental damage, minimize pores, restore moisture and revitalize the skin while you sleep. Visibly reduces the appearance of deep wrinkles and fine lines from the first application while helping to relax and diminish the appearance of facial expressions that may lead to crows feet, brow furrow wrinkling, laugh lines, frown lines, and other skin creases. Leaves skin looking soft, smooth and years younger.

Key features

  • 4% Syn-Ake, synthetic neuropeptide that mimics the wrinkle relaxing properties of an enzyme found in snake venom from the Brazilian Viper
  • 10% Snap-8 30%, more effective than Argireline; This neuropeptide helps reduce the depth of wrinkles caused by facial expressions
  • 3% Argireline, a Neuropeptide and Hexapeptide cocktail that prohibits muscles from contracting which prevents the formation of lines and wrinkles

Honest reviews


Major improvement in just a few days

I’ve tried quite a few anti-aging moisturizing creams but none have shown significant improvement such as this product. PTR has a thick creamy consistency. It goes on smoothly with no fragrance and absorbs fast. I could see a big difference in a few hours – face skin more smooth and silky, pores reduced somewhat and just overall improvement in skin tone and color. I had some discoloration from previous dry patches and within a couple of days using PTR, the patchiness in color was totally smoothed out. I originally purchased this at full price (ouch!) and was happy to see it on Amazon at the reduced price. My face is loving this new cream! I’ll update later on if my opinion changes. I also ordered the PTR peel pads and hope they live up to the very positive reviews.

Pat Beresford, SD


I’m 58 years old. I alternate the use of this cream every other night with the mega rich anti-aging cellular cream (also by Peter Thomas Roth). This cream is unscented, not too thick (it has some consistency to it though) and it doesn’t get sticky on your face. Once applied your skin drinks it up quickly and gets shiny. It does tons of good to my skin. My complexion is more supple, soft, luminous and firm. The expression lines have been dramatically smoothed out. No allergies or breakouts (I’m very prone to it). Recomended.

Lorraine Paris, TX

Very nice wrinkle fighter…and a little bit goes a long way

I use this night cream in conjunction withPeter Thomas Roth’s Laser-Free Resurfacer with Dragon’s Blood Complexevery night before bedtime. It goes on very smoothly and it only takes a tiny amount to smooth over your skin, which is a good thing since it’s not an inexpensive moisturizer. In fact, the cream has a stiff enough consistency in its small container that when you run your finger over the surface, only a small amount comes away…so it is actually a bit difficult to use too much.This un-wrinkle night cream contains retinol, glycolic acid, vitamins, and skin moisturizers. It’s formulated to support natural cell turnover, repair daily environmental damage, minimize the appearance of pores, retain moisture, and revitalize skin while you sleep. I’m really happy with the results that the PTR skincare products are giving my skin.I would have rated it 5 stars, but the one thing I don’t care for is the shine that it gives my face for quite a while after applying.

Alisha Saugerties, NY

First Night moisturizer that makes me skin Glow come morning- and with Retinol- what could be better.

This isn’t greasy, but it is thicker then some day moisturizers. Peter Thomas Roth always has high quality ingredients, formulated in his own labs, and breakthrough products. As a brand I strongly recommend him…. as a product this is the best. All your nutrients, as well as Retinol for anti-aging- this is truly the first product that has made my skin glow when I wake up in the morning. And no night "lines" on my face… or around my eyes. PTR also is known for using the highest levels of the effective ingredients for real results- not just a drop or two. I am a PTR fan and always will be- found him trying a sample product, and while not 100% of my skin care product are PTR, I’ve got a pretty good collection to choose from– but start with this if you’re looking for a night cream!

Erica Java, VA

Good Adjuvant to the turbo serum

This night time creme is probably the most hydrating creme that I’ve used. It is not as powerful as the turbo serum that I apply in the morning but, unlike the serum, this nourishes and softens the skin whereas the turbo tightens it. The two are a great combo.

Elisa Brookville, OH

Good stuff

Peter Thomas Roth can be rather expensive. But I feel this product is worth every penny. It really makes a difference to my mature skin.

Lupe Faith, NC

nice cream

Very nice texture, no smell, feels good.My skin looks great but I haven’t remembered to apply this cream every day….

Susie Star Lake, WI