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derma e Deep Wrinkle Peptide Moisturizer Crème, 2 Ounce

This double action moisturizing crème with two powerful peptides Palmitoyl Pentapeptide (Matrixyl™) and Acetyl Hexapeptide (Argireline®), saturates skin with nutrients and visibly softens even the deepest lines and wrinkles.

Key features

  • Double action moisturizing crème
  • Saturates skin with nutrients and softens the deepest wrinkles
  • Helps to increase collagen and elastin production
  • No animal testing
  • Made in USA

Honest reviews


Soothing and smoothing

Very soothing compared to other moisturizers, and great for smoothing fine lines! I periodically get facials and every facial before this last one they have been concerned about my dehydrated skin. But on my most recent visit (after using this product) the facialist said my skin was looking much better!

Brandie Trenton, GA

It works!

At age 63, my mother was spending $200 of her hard earned money annually on department store brands. It didn’t seem right that half of the purchase price went straight to brand marketing. She is not fluent in English, so I conducted a search on her behalf.After screening dozens of face creams for safe and effective ingredients via the Skin Deep database, this particular cream stood out for its avoidance of parabens and skin firming acids. It works well with her sensitive skin and helps it stand up to the Southern California desert climate. It’s even firmed up her wrinkles. Her skin is clearer, as in significantly less spots. She and her friends are now converts. Thanks Derma E.Update- It’s been about 6 years since my mother started using this cream. She still looks 12 years younger than her age, but there are definitely visible fine lines. For 69, fine lines are a good problem to have. She is a religious sun avoider, carying sun hats and parasols everywhere she goes. I attribute her behavior to why this cream was so efficacious.

Irene Pine Grove Mills, PA

Another great Derma e Product!!

Great for sensitive skin, but actually has an effect! In only a few days, I don’t have those little crepey lines around my mouth! I sent back some very expensive products to one of those network shopping places after getting this product! I can compare this to some other skin creams I have paid over $100 for! Seriously, this is scary! I am trying several other Derma e products as they are great bargains and very high quality. This stuff works! (We all need to review when we buy, because I only bought when I read others’ reviews! Come on “gals”, review the beauty items when you buy!!)

Margret Brinson, GA

I am a little disappointed

I am 29 years of age and I truly was hoping that this product will work at leat ok based on other reviews. I was not expecting a miracle, but at least some mild results, but I was truly disappointed. I purchased this derma e peptides and the night version too; but it did not work. It has some kind of consistency that “temporarily” gives the impresion that is working, but soon I found out that it was an illusion. It seems to cover some mild wrinkles but the effect is gone in probably two hours (I can obtain this result with good makeup). Oh well, good luck to all of you, I am sure that there must be something out there I just have to keep trying!

Ashlee Austin, PA

Great product

Good. Stuff!!

Estella Gordonsville, VA

This really works almost as well as promised.

I say “almost” because I’m not sure anything can “reverse” wrinkles, especially for someone like me in my sixth decade. But I do believe it retards the wrinkling process and at the same time gives your skin a great feel and texture. It almost pinks it up a little, but not in an irritating way. I even like it better than most Olay Regenerist skin products, with the exception ofOlay Regenerist Daily Regenerating Serum, Fragrance Free, 1.7-Fluid Ounceswhich is, for me, the best thing I’ve ever tried for improving skin texture. This derma e product, however, improves texture and moisturizes at the same time. Good stuff!

Sherrie Pond Gap, WV

derma e Peptites Plus Double-Action Wrinkle Reverse Creme

I was looking for a good eye and face moisturizer that had the ingredients that I was looking for and this fits the bill. My skin is brighter the darkening circles I seem to get in the winter have faded and I just love how it makes my skin feel. I don’t have any wrinkles so can’t offer up any insignt in that area, but this creme is great and a little bit goes a long way.

Brittany Waldport, OR

Leaves Your Face Very Soft

The Derma E Peptide Plus Double-Action Wrinkle Reverse Cream has been keeping my face feeling soft, reducing the wrinkles around my eyes, and doesn’t dry my skin out. I started with this day cream but I just purchased the Night Hydraulonic acid creme to see if I get better results. So far so good. It would be nice to have an SPF of 30 in these products so I’m using a sunscreen on top of the moisturizer. My skin is very fair and sensitive and this product is doing it’s job! I really want to take care of my skin even though I’m 32 with a few wrinkles. I look forward to the Vanilla Bean Cleanser I purchased as well. Will review everything I use.

Mayra Sonoita, AZ

Wonderful for softening my skin

I really love this moisturizing cream and use it day and night. The shuttle ylang ylang essences is calming as well

Jesse West Hartford, VT

This cream really works well.

I have been using this cream for a couple of years and it works really well for moisture and plumping up fine lines. I also use it with my Light Stim which is a hand held light that produces collagen to get rid of your laugh lines, in between eye lines, and fine lip lines. This cream is a must have for that purpose. The price is awesome as well and a little goes a long way. It has all the necessary ingredients as higher priced creams. Derma e is a very reputable company with paraben free products.

Sylvia Fairforest, SC

good product

I try this cream 3 days ego its fill nice in face let me use for longer time its good cream for this price

Tiffany Nancy, KY

Works quite well

Yes this cream does have a peculiar odor (not that bad though) when you first put it on but it quickly dissipates. I think it works as well as Hydroxytone for a fraction of the price. My skin feels firmer and smoother. I will definitely be reordering this product.

Della Brunswick, NE

skin repair

I use this moisturizer almost every morning. It goes on smoothly and penetrates the skin very quickly. I want to say that my skin is more elastic since using this product.

Juana Leroy, AL

Love it

I’ve been using it and reordering it. Will continue to use it. I really don’t think it reverses deep wrinkles but it does soften them……I have really deep wrinkles.

Jodi Redwater, TX

Love this product!

I am now a Derma-e fan! This is my second time ordering this face creme. I always order creams and then there is something about them I don’t like and I never finish them. This is the first one I’ve actually finished and ordered again. It’s not too light or too thick and I like the smell. I heard that peptides are the way to go to help rejuvenate collagen so I went with this product. It also doesn’t have a lot of the extra ingredients you can’t pronounce, which is important for me to stay away from and one of the main reasons I bought it in the first place. I HIGHLY recommend this product and I will continue to buy Derma-e from now on. And, even though this is a 2 oz, a little goes a long way so it lasts me a while.

Joy Belleville, IL