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Botox Alternative:hyaluronic Acid,15% Matrixyl 3000, 20% Argireline,5 % Vitamin C,repair, Boost Collagen, 1oz Serum

1oz serum Our Advanced Wrinkle Defense Serum provides you with short and long term improvement in the appearance of wrinkles and contains blend of 20% Argireline and 15% Matrixyl3000. Argireline® works similar to Botox because it reacts with the muscles that makes wrinkles worse. Collagen also helps the skin rejuvenate itself as the building blocks to repair that lose skin under the eyes and around the lips. 100% Hyaluronic Acid -Super hydrates and increases the skins ability to retain moisture. (the HA will transport the active ingredients in your serum more effectively into your skin. Helps advance collagen and elastin production Boosts the skins complexion Tones, refreshes and purifies the skin Protects from moisture loss Wakes tired and fatigued eyes

Key features

  • Made in the USA-Contains 15% Matrixyl 3000, 20% Argireline and 5% vitamin C in pure Hyaluronic acid serum
  • Matrixyl 3000 increases skin elasticity and tone, and has been shown to reduce wrinkles & skin roughness
  • Argireline ARGIRELINE (known as the Natural Botox) REDUCES THE APPEARANCE OF FINE LINES & WRINKLES , Giving You a Smoother Face in 1 month with none of the side effects that Botulinum toxin injections are associated with AND.. without the injections,
  • 100% Hyaluronic Acid -Super hydrates and increases the skins ability to retain moisture. (the HA will transport the active ingredients in your serum more effectively into your skin.
  • Put these Three ingredients together and you have the perfect anti aging care product to help skin to look younger and as Dr Oz recommends, look years younger.

Honest reviews


Great product!

I purchased the Protoxyn Anti-Aging Serum approximately 10 days ago and have used it every day morning and in the evening. I first heard about the benefits of argireline from a plastic surgeon that was a guest on the Dr. Oz Show. He recommended using a serum with at least a 10% argireline content. This plastic surgeon said the results would be similar to Botox. I was skeptical. After using it approximately 10 days, I really do see a difference. This serum also contains Vitamin C which is very beneficial to your skin and Matrixyl 3000 which promotes collagen growth. Make no mistake about it, it’s not surgery or botox, however, my lines are much less noticeable and what I noticed most is my eye area and forehead. I do get botox treatments but I feel with this product I can stretch my treatments further apart which will save me money. I do use and have tried a lot of products. However, it wasn’t until this argireline that I really could see a vast difference. If you try this product, you need to be diligent about using it every day. Use a good moisturizer after a few minutes. I use Lamer cream with this serum. You will start noticing a difference in a few weeks. I’m in my late forty’s and frantically trying to stop the aging process. Anyway, it works for me and if you are up there in age, it is worth a try. I’ve used several expensive products and this worked much better. I really like this product and I will continue to order this.

Gloria Shawville, PA


At first, i have to ADMIT,i was NOT impressed with it…So i kept using this for a month..Im happy with this..I use this first, then i Add my Night creme,This is not greasy at all,It really Absorbs Really good..You really Need to give this stuff a whole month, before Judging it to fast..It makes my face Tingle With cheer !! haaI dunno,At first i was Going to Throw it in the Garbage LOLthen i thought, I better Use it longer..I really think it Works better with a Creme to,Even if its Ponds,I wear make up every day & i use Noxema to take it off,& then i add this Stuff & i let it Dry a min then i add my Cremes,Sometimes Ill use Ponds,Ponds seems to me, it works with it as a team….So,Thats my True Feelings !!!HEY ALL,IM ON MY THIRD BOTTLE & LOVE IT !!I DO USE CREME OVER IT,ALTHOUGH SOMETIMES JUST THIS !!!!!!!

Aurelia Millstadt, IL


Waste of money. I have been using it religiously twice a day for a month. No changes in my skin, no reduction in wrinkles at all.

Aisha Plumtree, NC

Seriously Botox? I think not…

Well I’ve never used Botox as the whole concept terrifies me but I don’t love my wrinkles either. I thought this stuff might actually work and I have to say that for me it doesn’t. It’s nice, and maybe the effects are cumulative but for right now I haven’t seen that huge a difference… sad to say

Lelia Walstonburg, NC

Hate how it pulls up over serum and under moisturizer

Since this is a gel, I apply it over my serums, and under moisturizer, but it just pills up making day makeup application impossible. The SkinScience line had much better serum

Melba Hoyleton, IL

Works good, I guess

I’ve been using this product for a couple months after I was tired of spending $50+ dollars on Lancme serum. It worked great at first. I noticed dark spots fading around my mouth and wrinkles seemed to become finer. No major changes though. Now the product has slowed in its ability to further remove my dark spots. I will order it again though because I had the same results with the Lancme serum. I have now combined a cleanser with glycolic acid to get rid of those stubborn dark spots.

Isabella Burlingham, NY

I love this product! But no, it’s not Botox.

I really like this product. No, it’s not an injection. I agree the marketing is a bit confusing. You will NOT get the results of an injected product with a topical product. So you have to have realistic expectations. That said, Argireline can reduce motion and softens wrinkles. (Reduce, not completely freeze or eliminate.)I’ve reordered this product and don’t want to be without it! I bought it because of the 20% Argireline. I can’t afford Botox and would rather skip the injections. It may take a while to “build up”. I think I noticed results after a couple weeks. I use the product only on my forehead and I layer applications. This product is a bit thick and feels sticky at first, but it soaks in quickly and very cleanly. So I put one layer on my freshly washed face and let it dry. I add another thin layer and let it dry. Sometimes I’ll add a third layer just focusing on the forehead “11s”. Then I can put moisturizer over. This is all for a.m. application, and keep in mind that I have very strong “frown muscles”. It doesn’t completely freeze my forehead, but it definitely softens the “frownies”!!! I honestly notice a difference.Though I do multiple applications, I do only focus on my forehead, so one bottle still lasts a couple months. I use Porcelain Skin’s Skin Firming Activating with DMAE, Alpha Lipoic Acid, Vitamin C, and Hyaluronic AcidB00A7LPEMGon the rest of my face.With these products, as well as alternating Tretinoin cream and a glyocolic cream at night, my skin is looking good!

Marlene Bulpitt, IL



Candace South Fork, PA

used it all

never saw any difference at all even my family members were watching to see if it worked and they didnt see a differencedejuan neilson280 wheeler rdgray, ga 31032

Lolita Las Marias, PR

Great value !

It really helps hold in moisture and helps your moisturizer stay on better too. I will reorder this product. Only takes a little product.

Sheila Oakwood, OK

Save your money

From what I had read about this product I was looking for noticeable results in no time. Been using it now for about 6 weeks and haven’t seen a difference in my skin tone, texture, or tautness or wrinkle size. I’m very disappointed. Don’t waste your time or your hard-earned cash.

Hester Ventnor City, NJ


There are other things for your skin that have much more research behind them, plus the clear packaging is unstable anyway. And nothing- NOTHING- is a botox alternative. Think about it- you wouldn’t be able to move your hands if it REALLY worked like botox.

Millie Hurlock, MD

Works great!

I have bought this a week ago and already see and feel a difference. Will be buying more! Thank you so much!! 🙂

Lola Mutual, OK